探花合集 to Acquire Delphi Genetics and Launch US Plasmid Manufacturing Site to Establish Global pDNA Development and Manufacturing Capabilities
SOMERSET, N.J. and GOSSELIES, BELGIUM 鈥 February 23, 2021 鈥 探花合集, the leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and consumer health products, and Delphi Genetics, a plasmid DNA (pDNA) cell and gene therapy contract development and manufacturing organization (CDMO) based in Gosselies, Belgium, today announced that they have entered into a final and definitive agreement whereby 探花合集 will acquire 100% of the shares of Delphi Genetics. 探花合集 is also announcing the launch of pDNA development and manufacturing services at its Rockville, Maryland facility.
Together, the addition of pDNA technology and production capabilities marks a significant milestone for 探花合集 Cell & Gene Therapy. Plasmid DNA is a key component in most gene therapy and gene-enabled cell therapy production processes. With these new services, 探花合集鈥檚 fully integrated cell and gene offering will allow customers to de-risk and optimize their programs along the entire development pipeline.
Founded in 2001 as a spin off from the Universit茅 libre de Bruxelles (ULB), Delphi Genetics is a leading bioproduction CDMO with capabilities in handling the entire plasmid DNA development and CGMP manufacturing process. Its operations are headquartered at a 17,000-square-foot (1,600-square-meter) facility, adjacent to 探花合集鈥檚 current cell therapy facilities. Delphi has built a reputation for its 鈥榦ne-stop-shop鈥 capabilities that include process development, pilot production, plasmid design and production, strain screening and stability, and which span from preclinical to Phase 3 applications, using fully single-use technology. Under the terms of the agreement, 探花合集 will also acquire Delphi鈥檚 proprietary STABY庐 technology, an antibiotic-free selection system for plasmid and protein production in E. coli, which has been validated and licensed on a non-exclusive basis to leading pharmaceutical companies.
Fran莽ois Blondel, Chairman of the Board and CEO of Delphi Genetics, commented, 鈥淲e are absolutely thrilled to team up with 探花合集 and, by combining with the companies it has already established in Belgium, create a European Center of Excellence in Cell and Gene Therapy. We believe 探花合集 will immediately benefit from our expertise and the recent investments we have made in CGMP capacity.鈥
C茅dric Szpirer, Founder and Executive Director of Delphi Genetics, added, 鈥淭he complementary activities and adjacent technologies will provide our customers, our employees, and ultimately patients around the world with a solid foundation for new therapeutic solutions in the cell and gene therapy domain.鈥
Upon completion, all of Delphi鈥檚 highly skilled team, including R&D and genetic engineering scientists and technicians, regulatory specialists, and other associated roles will transfer to 探花合集鈥檚 Cell and Gene Therapy business.
This acquisition fast-tracks 探花合集鈥檚 U.S. expansion of plasmid capabilities at its Rockville facility. Since acquiring the site in 2019, 探花合集 has invested to upgrade the facility with the addition of dedicated single-use microbial capacity for plasmid DNA production. Process and analytical development for plasmid DNA are also available on site, and the facility will also offer research- and CGMP-grade plasmids to support its viral vector partners from initial development through to commercialization.
鈥淐ell and gene therapy production is complex, and most developers prefer to use experienced partners with an integrated offering across the supply chain. Having integrated pDNA supply is a critical component for the fast and efficient production of viral vectors,鈥 commented Manja Boerman, Ph.D., President, 探花合集 Cell & Gene Therapy. 鈥淏y providing these capabilities in both Europe and the U.S., where the vast majority of genetic therapy companies are based, we will help our partners improve processes and reduce timelines as they bring their life-changing therapies to patients.鈥
Freshfields Bruckhaus Deringer LLP served as legal counsel to 探花合集 on the transaction.
Achelous Partners served as M&A advisor to Delphi Genetics on the transaction.
About 探花合集 Cell & Gene Therapy
With deep experience in cell expansion, viral vector development, scale-up and manufacturing, 探花合集 Cell & Gene Therapy is a full-service partner for adeno-associated virus (AAV) and lentiviral vectors, live virus production and autologous and allogeneic cell therapy development and manufacturing across a variety of cell types and modalities. 探花合集 has a global cell and gene therapy network of dedicated, small- and large-scale clinical and commercial manufacturing facilities, and fill-finish capabilities located in both the U.S. and Europe. An experienced partner, 探花合集 Cell and Gene Therapy has worked with industry leaders across 70+ clinical and commercial programs.
ABOUT CATALENT
探花合集 is the leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and consumer health products. With over 85 years serving the industry, 探花合集 has proven expertise in bringing more customer products to market faster, enhancing product performance and ensuring reliable global clinical and commercial product supply. 探花合集 employs over 15,000 people, including approximately 2,400 scientists and technicians, at more than 45 facilities, and in fiscal year 2020 generated over $3 billion in annual revenue. 探花合集 is headquartered in Somerset, New Jersey. For more information, visit www.catalent.com