探花合集 Pharma Solutions, today announced that it is to evaluate Jupiter Orphan Therapeutics, Inc.鈥檚 (JOT) novel formulation of resveratrol, JOTROL, for delivery using 探花合集鈥檚 R.P. Scherer softgel technology.
JOTROL, which is being developed to remedy resveratrol鈥檚 poor bioavailability and dose limiting gastrointestinal side effects, is being studied in multiple pre-clinical and clinical trial programs in progress for the treatment of rare diseases linked to single gene deficiencies. These include Friedreich鈥檚 Ataxia and Mucopolysaccharide (MPS) diseases, as well as partner programs for treatments in pancreatic cancer, Machado-Joseph and Alzheimer鈥檚 disease.
Under the arrangement, 探花合集 will assess both conventional softgel and 探花合集鈥檚 proprietary OptiShell庐 gelatin-free technology, which allows for higher fill temperatures and pH, and therefore can accommodate semi-solid and highly viscous formulations, and a wider range of excipients designed to improve bioavailability and stability.
鈥淒eveloping better treatments that improve patient experience and lead to better real world outcomes is vital for drug innovators鈥 success,鈥 commented Dr. Aris Gennadios, 探花合集鈥檚 President of Softgel Technologies. 鈥溙交ê霞 is dedicated to using our breadth of formulation technology expertise and experience across thousands of innovative molecules to improve patient acceptance and adherence.鈥
Christer Ros茅n, Chairman, CEO and Founder of JOT added, 鈥淲e selected 探花合集 as our development partner for our JOTROL therapies because of their breadth of experience in formulation and softgel technology, coupled with their wide range of complementary capabilities.鈥
探花合集 will conduct its work on JOTROL from its primary, 453,000 square feet, North American softgel development and manufacturing center-of-excellence in St. Petersburg, Florida, where the company offers formulation development and manufacturing of prescription and over-the-counter softgels, and has an annual capacity of more than 18 billion capsules a year.
Media Contacts:
Chris Halling
+44 (0)7580 041073
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Richard Kerns
+44 (0) 161 728 5880
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Christer 鈥淐hris鈥 Ros茅n
+1 (561)308 7780
[email protected]
About 探花合集
探花合集 is the leading global provider of advanced delivery technologies and development solutions for drugs, biologics and consumer health products. With over 90 years serving the industry, 探花合集 has proven expertise in bringing more customer products to market faster, enhancing product performance and ensuring reliable clinical and commercial product supply. 探花合集 employs approximately 9,500 people, including over 1,400 scientists, more than 30 facilities across five continents, and in fiscal 2016 generated $1.85 billion in annual revenue. 探花合集 is headquartered in Somerset, New Jersey. For more information, visit www.catalent.com
More products. Better treatments. Reliably supplied.鈩
About Jupiter Orphan Therapeutics
Jupiter Orphan Therapeutics, Inc. (JOT) is a clinical stage specialty pharmaceutical company developing therapies for rare diseases linked to single gene deficiencies. JOT, a Delaware Corporation with its principal office located in Jupiter, FL, USA, was founded in the summer of 2015. In its short period of operations, JOT has assembled a very strong management and scientific team as well as defined five pipeline products which of one is already in Phase II.
JOT is developing treatments for various different orphan diseases such as Friedreich’s Ataxia and MPS1. Orphan diseases are defined in Law as a disease that affects less than 200,000 people in the USA. Other areas in the world have similar laws. Although the incidence of orphan diseases may be small, the effects on the afflicted and society are profound.
JOT has developed a unique formula, JOTROL, for the well-known natural product resveratrol that has many observed pharmacologic effects. Resveratrol is a dietary polyphenol found in grapes, red wine, berries and nuts. It has several postulated effects such as anti-cancer, anti-diabetic, cardioprotective, antioxidant, neuroprotective as well as clinically showing a prolonged lifespan in mice. It has, however, poor bio-availability in humans and at high doses causes GI side effects.
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